Similar to those results of LPS stimulated-RAW264.7 cells, PHI (100mg/kg) treatment significantly reduced the expression level of TLR4 protein and the phosphorylation levels of Src, p65, IκBα, p38, and JNK proteins in colon tissues of colitis mice (Figure 9A–C, P < 0.05). The gene discussed is MAPK8; the disease is colitis.