MALAT1 and Cowden disease: Li et al. [65] demonstrated that a long noncoding RNA (lncRNA), MALAT1, is abnormally downregulated in the intestinal mucosal tissues of CD patients and in DSS-induced colitis mice; the mechanism of action of MALAT1 is to sequester miR-146b-5p and maintain the expression of apical junction complex [AJC] proteins.