Some studies found that alteration of folate-metabolism-related enzymes affecting genomic stability was closely related to the function of DNA repair pathways in cancers, such as methylenetetrahydrofolate reductase (MTHFR) [122,123], prostate-specific membrane antigen (PSMA) [124], mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) [125] and Folylpolyglutamate synthetase (FPGS) [126]. Here, FOLH1 is linked to cancer.