The expression of Ifnar1, Ifngr1, tnfaip2 and tnfaip3 was significantly (p < 0.05) increased in the MOS200 or MOS400 groups post-A. hydrophila infection, especially at 4 hpi, while that of most DEGs in the control group showed no significant (p > 0.05) difference upon infection. The gene discussed is TNFAIP3; the disease is infection.