A second study by van der Plas et al. [34] included 70 controls, 13 individuals with pre-manifest DM1 (PreDM1), and 40 patients with DM1, with the assessment of plasma levels of NfL, T-tau, GFAP, and ubiquitin C-terminal hydrolase-L1 (UCH-L1) by SiMoA. The gene discussed is UCHL1; the disease is myotonic dystrophy type 1.