They have been extensively studied in various neurodegenerative disorders: the highest increase of T-tau was found in Creutzfeldt–Jakob disease (CJD) and Alzheimer’s disease (AD), a mild-to-moderate increase in frontotemporal (FTD) and Lewy body dementia (LBD), while normal levels were found in Parkinson’s disease (PD) and progressive supranuclear palsy (PSP). Here, MAPT is linked to Classical progressive supranuclear palsy.