A reciprocal relationship between Cx46 and Cx43 has been postulated in the differentiation of glioblastoma cancer stem cells, in which Cx46 is expressed predominantly in undifferentiated glioblastoma cancer stem cells and Cx43 in non-cancer stem cells, suggesting that the Cxs expression specificity in processes such as differentiation are crucial [83]. This evidence concerns the gene GJA1 and cancer.