Analysis revealed that CD22 expression was significantly associated with the size of the tumor (χ2 = 4.163, p = 0.041), while no significant associations were found with other clinicopathologic features, such as age (χ2 = 0.556, p = 0.456), lymph node metastasis (χ2 = 0.692, p = 0.707), histologic grade (χ2 = 1.740, p = 0.419), clinical stage (χ2 = 1.267, p = 0.260), and Ki67 expression (χ2 = 0.000, p = 1). This evidence concerns the gene CD22 and metastatic malignant neoplasm in the lymph nodes.