It was shown that soon after infection with human RSV (hRSV, a negative-strand RNA virus of the Pneumoviridae family, within the Mononegavirales order that causes bronchiolitis in children), RIG-I and MDA5 colocalize with viral genomic RNA and N protein, and, at a later step of infection, contribute to form large viral IBs [68]. The gene discussed is RIGI; the disease is bronchiolitis.