DPYD and pancreatic ductal adenocarcinoma: Kato et al. modeled N-nitroso-bis(2-oxopropyl)-amine-induced hamster pancreatic ductal adenocarcinoma (PDAC) and found that luteolin targets a novel STAT3–dihydropyrimidine dehydrogenase (DPYD) pathway, making it a promising chemo-prophylaxis agent for PDAC [105].