The upregulated genes are involved in the modulation of transcriptional activity (Bcl3, Spen), histone acetylation (Dot1l, Kmt2d), protein phosphatase activity (Dusp6, Ppp1r10), mitochondrial biogenesis and function (Lars2, Pprc1), extracellular matrix remodelling (Egfl7, Ntn3, Papln), muscle cells differentiation (Myoz2, Tmod4), and cancer progression (Sez6l2). This evidence concerns the gene PAPLN and cancer.