KMT2D and cancer: The upregulated genes are involved in the modulation of transcriptional activity (Bcl3, Spen), histone acetylation (Dot1l, Kmt2d), protein phosphatase activity (Dusp6, Ppp1r10), mitochondrial biogenesis and function (Lars2, Pprc1), extracellular matrix remodelling (Egfl7, Ntn3, Papln), muscle cells differentiation (Myoz2, Tmod4), and cancer progression (Sez6l2).