In a murine model of colitis carcinogenesis, STAT6-deficient (Stat6−/−) mice exhibited fewer and less aggressive tumors, which was associated with a decrease in the mobilization of inflammatory monocytes (CD11b+Ly6Chi) and granulocytes (CD11b+Ly6G+) compared with wild-type animals. The gene discussed is ITGAM; the disease is colitis.