TLR4 and Multiple Organ Failure: Moreover, S100A8/A9 has been demonstrated to inhibit cell growth, cause cytotoxicity and induce apoptosis through the activation of the danger signal receptors such as Toll-like receptor 4 (TLR4) or the receptors for advanced glycation end-products (RAGE), thereby eliciting a variety of inflammatory responses and causing endotoxin-induced multiple organ failure [4,6].