NK cells can recognize tumor cells based on a balance between stimulatory and inhibitory receptors [stimulatory receptors: DNAX accessory molecule 1 (DNAM1), 2B4 (also known as CD244) and NK group 2D (NKG2D); inhibitory receptors: killer cell immunoglobulin-like receptors (KIRs), TIGIT, killer cell lectin-like receptor subfamily G member 1 (KLRG1), T-cell immunoglobulin mucin family member 3 (TIM3), and programmed death 1 (PD1)] [72,73] (Figure 2). Here, CD226 is linked to neoplasm.