Barsoum et al. reported that reduced nitric oxide levels in prostate cancer cells induced another intracellular checkpoint molecule, hypoxia-inducible factor 1α (HIF1α), which augmented a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) expression and significantly increased MICA secretion in the extracellular milieu [106]. Here, ADAM10 is linked to Familial prostate cancer.