TNF and neoplasm: Barrow et al. also reported that platelet-derived growth factor (PDGF)-DD engagement of NKp44 triggered NK cell secretion of interferon (IFN)-γ and tumor necrosis factor alpha (TNF-α), and a distinctive transcriptional signature of PDGF-DD-induced cytokines and the downregulation of tumor cell-cycle genes correlated with NCR2 expression and greater survival in glioblastoma [82].