UGCG and breast cancer: Indeed, the GlcCer synthase inhibitor 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) was able to restore the sensitivity of BC cells to vinblastine treatment [31] and stimulate autophagy in MCF-7 cells [70], whereas combinations of inhibitors of GCS with 4-HPR, which, as previously reported, is known to elevate Cer and dhCer levels, were reported to synergistically suppress the growth of various human cancer cells, including BCs [106].