PLEKHA8 and breast cancer: Since the transport of GlcCer into Golgi for the synthesis of LacCer, and then of neutral GSLs, which determine the lipid composition of the plasma membrane [99], is mainly mediated by phosphatidylinositol-4-phosphate adaptor protein 2 (FAPP2), a potential new strategy for inducing BC cell death might be targeting FAPP2 and hindering the synthesis of neutral GLSs.