CERT1 and breast cancer: Moreover, two studies produced evidence that CERT knockdown was able to sensitize HER2+ BC cells to Dox- or paclitaxel-induced cell death through the induction of Cer-mediated ER stress or lysosome-associated membrane glycoprotein 2 (LAMP2)-dependent autophagic flux [101,102], and a study indicated CERT as a useful predictor of response to neoadjuvant paclitaxel for primary TNBC [103].