CERS2 and neoplasm: Furthermore, since V-ATPase acidifies endosomal-lysosomal organelles and the microenvironment of tumor cells, promoting not only tumor invasion and metastasis but also chemoresistance [91], the elevated lysosomal and extracellular pH due to the inhibition of V-ATPase by CerS2 in Dox-treated MCF-7/Adr cells could be the mechanism which facilitates cellular entry and nuclear localization of Dox [37].