Moreover, these authors have found that both S1PP1 and LPP3 showed a prognostic value highly dependent on BC intrinsic subtypes, pathological grades, and lymph node status; in particular, SGPP1 and LPP3 expression decreased in primary tumors compared to normal breast tissues, with major reduction in TNBC subtypes and stage IV patients [77]. This evidence concerns the gene PLPP3 and breast cancer.