CERS2 and breast cancer: Although it cannot be excluded that the concerted activity of the different CerS isoforms may be influenced by the formation of heterodimers of CerS family members [93], a recent study has shown that the qualitative and quantitative expression of different CerS2 transcripts produced via alternative splicing (AS) could explain the contrasting effects (pro- and anti-proliferative, pro- and anti-apoptotic) of very long chain-Cer and then play a crucial role in BC pathogenesis [94].