More recently, Vethakanraj et al. [117] have further substantiated the apoptotic activity of ceranib 2 in MCF 7 and MDA MB 231 cell lines, demonstrating that the anticancer effect of ASAH1 inhibitor ceranib-2 in both these tumor cell lines was due to the activation of SAPK/JNK, p38 MAPK apoptotic pathways and the inhibition of the Akt pathway. This evidence concerns the gene AKT1 and neoplasm.