Contrary to CerS6, elevated expression of CerS2, the only CerS that synthesizes Cer with very long acyl chains (C22:0, C24:0, C24:1), has been found in a strong positive correlation with the longer disease-free times and overall survival of the patients with respect to those with CerS2 negative tumors, and in a reverse relationship with tumor progression, lymph node metastasis and HER2 expression [37,38]. Here, CERS2 is linked to neoplasm.