CERS2 and neoplasm: Indeed, higher levels of the alternative spliced transcript for CerS2 (AS1 transcript), lacking exon 8, which confers catalytic activity and assists in substrate binding to synthesize very long chain-Cer, were found in Luminal B tumor tissues as compared to normal tissues, as well as in TPBC BT-474 cells as compared to normal MCF-7A cells, whereas the expression of normal CerS2 transcript (PC transcript) was not markedly different.