As S1P can elicit pro-survival signaling in BC by engaging with five specific G protein-coupled receptors (S1PR1–5) in an autocrine or paracrine manner [26], CDases could be used by cancer cells to their advantage by decreasing the levels of a tumor suppressor (Cer) and increasing the expression of a tumor promoter (S1P) [114]. Here, CBLN1 is linked to breast cancer.