FAS and breast cancer: Indeed, Tritz et al. [109] showed that FAPP2 downregulation increases tumor cell sensitivity to Fas-induced apoptosis in metastatic breast MDA-MB-231 cell lines, as well as showing that evidence exists that the invasive properties of MCF-7 are highly correlated with the globo-series GSLs SEEA3 and SSEA4, clustered in the GEMs, and the subsequent activation of focal adhesion kinase (FAK) in GEMs [110,111], whose levels were significantly up-regulated in TNBC and metastatic BC tissues and related to cancer recurrence [112].