PTK2 and neoplasm: In a more recent study, it has also been demonstrated that elevated levels of SSEA3 were significantly correlated with tumor progression and poor survival in patients, and that the globo-series GSLs in BC cells (MCF-7 and MDA-MB-231 cells) form complex membrane lipid rafts with caveolin-1 (CAV1) and focal adhesion kinase (FAK), which in turn interacts with AKT and receptor-interacting protein kinase (RIP), respectively [113].