These authors, who in a primary study demonstrated the association between elevated SMS2 expression and BC metastasis, subsequently reported that SMS2 promotes cancer cell proliferation by suppressing a Cer-associated apoptotic pathway, and cancer cell migration and invasiveness by enhancing EMT through the activation of TGF-β/Smad signalling pathway, in both MCF-7 and MDA-MB-231 cell lines and in vivo. The gene discussed is TGFB1; the disease is breast cancer.