We show here for the first time that the cholesterol and phospholipid contents of large HDL particles, calculated as HDL1-C/HDL1-apoA-I and HDL1-PL/HDL1-apoA-I, respectively, are significantly negatively correlated with the endothelial function in HV, but not in MS patients (Figure 3). This evidence concerns the gene APOA1 and myeloid sarcoma.