TGFB1 and neoplasm: MSCs secreted chemokine (C-C motif) ligand 7 (CCL7)/chemokine (C-C motif) receptor 1 (CCR1) to activate downstream CBP/P300 acetylation of KLF5 to promote CXC ligand 5 (CXCL5) transcription and secreted TGF-β to reverse the effect of KLF5 on transcriptional activation by regulating SMAD4, and CXCL5 promoted distant tumor metastasis and angiogenesis [115].