And reduced the level of Aβ in the hippocampus, the survival of hippocampal neurons was increased, and upregulation of BECN1/Beclin 1 expression in the AD model significantly enhanced autolysosome formation and clearance of Aβ in the AD model, leading to increased survival of neurons against Aβ toxicity [169]. This evidence concerns the gene BECN1 and Alzheimer disease.