MSCs-Exos accumulated in mediastinal lymph nodes, and histocompatibility complex (MHC)-II antigen-presenting cells (APCs) uptake induced Foxo3 activation via the protein phosphatase (PP)-2A/p-Akt/forkhead box O3 (Foxo3) pathway, and Foxo3 induced APCs to express IL-10, IL-33, and IL-34 and other cytokines and established Treg-induced ecotone in MLN, with enhanced Treg differentiation and cardiac targeting, thereby promoting cardiac inflammation regression and cardiac repair after MI [295]. The gene discussed is AKT1; the disease is myocardial infarction.