Expression of 5-HT7 mRNA increased by acute restraint stress but not by chronic variable stress in the rat hippocampus, indicating that 5-HT7 contributes to the regulation of response to stress [63]; however, the anxiety-like behaviour in the light/dark transfer or elevated plus maze tests did not affect both 5-HT7 knockdown or knockout models [55,64,65]. The gene discussed is HTR7; the disease is Anxiety.