Adipose MSC EVs induce M2 macrophage polarization by transferring signal transducer and activator of transcription (STAT) 3 that then transactivates arginase (ARG) 1 [58], protect from osteoporosis by carrying osteoprotegerin (OPG), which blocks osteoclast differentiation [59], and decrease liver fibrosis by suppressing stellate cell activation [104]. Here, TNFRSF11B is linked to osteoporosis.