Importantly, the authors identified a set of proteins found in the EVs of all cell types examined, such as the enzymes glucose−6-phosphate isomerase (GPI) and enolase (ENO) 1 and the membrane protein colony-stimulating factor 1 receptor (CSF1R), which may prove to be of use in isolating and characterizing circulating EVs relevant to metabolic disease [33]. Here, CSF1R is linked to metabolic disease.