Pancreatic EVs from healthy subjects reduce amyloid formation in the pancreas, a hallmark of diabetes [132], but conversely, EVs containing islet amyloid polypeptide (IAPP) can reach hippocampal cells, inducing a pro-fission status of the mitochondrial network and providing a link between diabetes and neurodegenerative disease [80]. This evidence concerns the gene IAPP and diabetes mellitus.