For example, there are reports that blocking neutrophil adhesion to endothelial cells with an antibody against lymphocyte function-associated antigen 1, the receptor for ICAMs, ameliorated cognitive loss in Tg mice [15] and that anti-VCAM-1 antibodies attenuated atherosclerosis in Apolipoprotein E−/− mice by inhibiting the adhesion of inflammatory cells [28]. This evidence concerns the gene APOE and atherosclerosis.