The results of this study provide evidence of the drug safety of JNJ in neuroblastoma cell cultures exposed to increasing concentrations of this molecule and of its potential neuroprotective effect against apoptosis and cell death, particularly decreasing the caspase 3 activation induced by DA and GLU and increasing and decreasing the number of viable and apoptotic cells, respectively, when cultures were exposed to GLU. This evidence concerns the gene CASP3 and neuroblastoma.