A study used micro RNA 146a (miR146a)/CeONPs nanocomposites to treat colitis on in vivo murine model (C57BL/6), finding that the nanostructure exhibited an anti-inflammatory and antioxidant activities, decreasing inflammatory cytokines; tumour necrosis factor (TNF) and interleukin 6 (IL-6), coinciding with the reduced oxidative stress [112]. The gene discussed is TNF; the disease is colitis.