The best-established neuroimaging method for the diagnosis of α-synucleinopathies is dopaminergic 123I-FP-CIT SPECT scanning, which can demonstrate a reduction in the levels of dopamine transporter in striatal neuronal pathways, in the bilateral caudate nucleus and in the putamen, both in individuals with PD and DLB [130,131]. The gene discussed is SLC6A3; the disease is Parkinson disease.