HAVCR2 and neoplasm: As expected, the results of the multivariate analysis confirmed the results of the univariate analysis and showed that, in addition to well-known factors associated with poorer prognoses and shorter OS (such as age at diagnosis, advanced stage of disease, the presence of metastasis and necrosis, a tumor size above 7 cm, and male gender), the presence of the C allele in the rs1036199 of TIM-3 is associated with shorter OS (Table 5).