The results showed that there were 10 up-regulated DEGs between metastatic and primary tumors, including ACTL6A, ANXA5, EPB41L4A-AS1, FAM217A, IFI27L2, LNX2, MED28, TACR1, TLE4, and ZNF763 (Figure 1C), and conversely, CREBBP was down-regulated between metastatic and primary tumors (Figure 1C), as well as in the resistant cancer cells (Figure 1D). The gene discussed is CREBBP; the disease is cancer.