MTOR and neoplasm: For example, a tumorigenic microglial phenotype may also be induced by the upregulation of the mammalian target of rapamycin (mTOR) pathway in GBM and by the downregulation of microglial sensome genes, such as sialic acid-binding immunoglobulin-like lectin-H (Siglech); these are critical for sensing tumor cells and their byproducts [101,102].