CD8A and myalgic encephalomeyelitis/chronic fatigue syndrome: There are studies that propose higher levels of long-chain fatty acid oxidation in memory CD8+ T cells supply additional energy needed for sustenance and proliferation after the removal of antigenic stimulation, but this may not reflect environments in vivo or the particular conditions in and around ME/CFS cells, since other important energy-producing metabolic pathways are disrupted in this disease [43,44,45,46,47,51,84].