SNCA and Parkinson disease: To investigate whether the α-synuclein-induced increase of ITPKB expression also occurs in PD patients, we extracted RNA from the cortex of 11 PD patients and 15 healthy controls (mean age: 79.1 ± 5.9 and 73.9 ± 7.3 years at the age of death for patients and controls, respectively; demographic description and clinical records are given in Table 1).