From a functional screen of PD risk genes in the C. elegans PD model eraIs1, we previously identified lfe-2, a sole ortholog of three human ITPKs (the neuronal ITPKA, the ubiquitously expressed ITPKB and the glial ITPKC), as a modulatory gene of α-synuclein-induced neurodegeneration. Here, ITPKB is linked to Parkinson disease.