ITPKB and neuroblastoma: We then analyzed ITPKB expression in human neuroblastoma cell lines in which wild-type or mutated SNCA is overexpressed and also determined mRNA level in postmortem cortex tissue originating from PD patients We found that a direct correlation in the expression of SNCA and ITPKB exists in both disease models thus suggesting that ITPKB may play a role in the pathogenicity of SNCA overexpression.