In nasopharyngeal carcinoma, DEPDC1 knockdown downregulated various downstream targets, such as c−Myc, BCL2, MMP2 and MMP9, which participated in proliferation, tumorigenesis, and metastasis [37], suggesting that DEPDC1 might be a vital factor in these biological processes. Here, DEPDC1 is linked to nasopharyngeal carcinoma.