Mitogen-activated protein kinase 8 (MAP3K8) is an indispensable member of the MAPK family and its overexpression has been widely implicated in the development and progression of numerous cancers, including prostate cancer, colorectal cancer, lung cancer, nasopharyngeal carcinoma, breast cancer, etc. [46,47,48,49,50]. The gene discussed is MAP3K8; the disease is Familial prostate cancer.