Zhang et al. reported that methylation of lncRNA KCNK15-AS1 promoted gastric cancer progression by modulating the KCNK15-AS1-DNMT1-MAPK and KCNK15-AS1-HDAC1-AKT axes, and treatment with 5-azacytidine and chidamide reversed this effect [68]. The gene discussed is DNMT1; the disease is gastric cancer.