It was shown to: (i) rescue mitochondrial functions and to preserve MAM integrity in human neural stem cells and an HD mouse model (YAC128) [101], (ii) reduce ER stress by modulating all branches of the UPR response in a mHtt (mutant huntingtin) cell line [102], and (iii) protect neurons from mHTT toxicity to decrease cell death [103]. The gene discussed is HTT; the disease is Huntington disease.