1: age, sex, SBP, LDL-C, HDL-C, smoking, and diabetes mellitus 2: model 1 + hsCRP and eGFR 3: model 2 + medications (angiotensin-converting enzyme inhibitor, angiotensin-receptor blocker, β-blocker, aspirin, or statin), number of stenotic vessels, myeloperoxidase, and BNP. The gene discussed is ACE; the disease is diabetes mellitus.