1: age, gender, and history of CAD2: pre-defined patient characteristics, cardiovascular risk factors, and medical history, including age, gender, body mass index, smoking history, positive cardiovascular family history, hypertension, hypercholesterolemia, history of diabetes, history of stroke, history of CAD, previous AMI, history of heart failure and adjudicated functionally relevant coronary artery disease* Both models also adjusted adding Cystatin-C. The gene discussed is CST3; the disease is familial hypercholesterolemia.