However, the gene expressions of osteogenic markers (BMP2, BMP4, RUNX2, ALPL, SPP1, and BGLAP), osteoclastic markers (TNFSF11, TNFRSF11A, and TNFRSF11B), or phosphate and pyrophosphate-related genes (SLA20A1, SLA20A2, AKNH, and ENPP1) were not upregulated in cardiac tissues from patients with ATTR-CA compared to those from AL-CA and non-CA patients (Figure 4). The gene discussed is SPP1; the disease is cancer.