In this complex cellular and molecular interplay, our research group has recently demonstrated that thrombopoietin (THPO), a humoral growth factor involved in the proliferation and differentiation of megakaryocytes in the bone marrow, appears as an additional crucial candidate mediator of platelet hyper-activation and immunothrombosis/thromboinflammation in COVID-19 [50]. The gene discussed is THPO; the disease is COVID-19.