A recent study supports our hypothesis by suggesting that ferroptosis signatures (e.g., SLC7A111, GPx4, ALOX5, P53, and RPL8) are enriched in platinum-tolerant ovarian cancer cells harboring stemness feature, and GPx4 is significantly upregulated in platinum-tolerant cells, xenografts, patient-derived xenografts, and high grade serous ovarian cancer specimens after neoadjuvant chemotherapy [39]. Here, ALOX5 is linked to ovarian serous adenocarcinoma.