NID2 and amyotrophic lateral sclerosis: First, the ALS patients were compared with H-CTR and NoH-CTR by a Wilkoxon rank sum test, showing that TARC and TIMP3 were significantly higher in the patients compared with the neurologically healthy controls (p < 0.05) (Figure 6a,c), while no significant differences were present for NID1 and NID2 (Figure 6e,g).