Recently, an increase in TIMP3 was reported in Alzheimer’s disease (AD) brains [74], while in the SOD1G93A mouse model of ALS, high levels of TIMP-3 were observed only in the early phase of the disease, reducing at later stages proportionally with the number of live motor neurons in the spinal cord [75]. Here, TIMP3 is linked to early-onset autosomal dominant Alzheimer disease.