The activation of epidermal growth factor receptor (EGFR) by AQP5 can stimulate the Ras/MAPK signal transduction directly or indirectly (via the activation of phosphoinositide 3-kinase (PI3K)) to lead to cell proliferation and migration of lung cancer cells [188] and human glioma cell lines [198], and keratinocyte chemoattractant expression [199]. This evidence concerns the gene EGFR and central nervous system cancer.