ATR and early-onset autosomal dominant Alzheimer disease: Regarding the WikiPathway database, the top 5 enriched pathways were: 5.51% of genes related to VEGFA-VEGFR2 signaling (q-value = 4.44−29), 3.47% related to miRNA effects in Alzheimer’s disease (q-value = 3.6−19), 2.39% related to breast cancer (q-value = 1.39−16), 1.75% related to the androgen receptor signalling pathway (q-value = 1.94−15), and 1.72% related to ionising radiation damage to DNA and the subsequent cellular response via the ATR Serine/Threonine Kinase (q-value = 8.38−17).