In a human stem cell models of tumor initiation, EWS–FLI1 was suggested to increase the expression of HOX (homeobox) genes crucial for correct embryonic development, and overexpression of a few HOX genes downstream of EWS–FLI1 has been linked to loss of H3K27me3 and the gain of H3K4me3 markers at the promoters of HOX genes [103]. Here, EWSR1 is linked to neoplasm.