Enhanced expression of endothelial cathepsin B and cathepsin L due to Fli1 deficiency has been shown to be associated with SSc vasculopathy, whereas downregulation of CTSB, CTSL, and CTSV in dermal fibroblasts implicates in SSc dermal fibrosis [43,44,45]. The gene discussed is CTSL; the disease is systemic sclerosis.