FLI1 and vascular disorder: In contrast, the progression of vasculopathy and fibrosis in SSc heart, lung, and skin due to Fli1 deficiency in fibroblasts and endothelial cells was accompanied by upregulation of CXCL6 [49], while CXCL13 (a chemokine for B cells, follicular T cells, T helper 17 cells, and regulatory T cells) expression was enhanced by Fli1 deficiency in peritoneal murine macrophages [50].