Thus, glycyrrhizin used for the treatment of hepatic diseases and itching dermatitis was shown to possess an anti-fibrotic effect in SSc dermal and lung fibroblasts via downregulation of Dnmt1, upregulation of Fli1, and induction of MMP1 gene expression via an ERK1/2-dependent mechanism [114]. Here, MAPK3 is linked to systemic sclerosis.