FLI1 and systemic sclerosis: Further in vitro studies have confirmed that FLI1 suppression induces SSc-like phenotypes in dermal fibroblasts, dermal dendritic cells, keratinocytes, endothelial cells, and macrophages, while in vivo findings have established that Fli1 deficiency is an important mediator of SSc-associated fibrosis [26,27,28].