The role of Fli1 as a natural negative inhibitor of collagen genes was supported by the fact that Fli1 protein levels were inversely proportional with COL1A1 mRNA and collagen 1 levels in the dermal fibroblasts of patients with SSc and in cultured fibroblast isolated from Fli1−/−, Fli1+/−, and Fli1+/+ mice embryos [29]. The gene discussed is FLI1; the disease is systemic sclerosis.