ACHE and Alzheimer disease: One of the typical hallmarks of AD is the loss of cholinergic neurons, along with the accumulation of beta-amyloid and hyperphosphorylated tau protein [106,107,108], as well as the increased activity of enzymes that hydrolyze acetylcholine in the synapses of cholinergic neurons—butyrylcholinesterase and acetylcholinesterase [109].