The silencing of these gene would contribute to NFk-B activation by inducing the transcription of proinflammatory genes such as TNF-, IL-1, IL-6, and IL-8, as well as disc degeneration by upregulating the expression of matrix-degrading enzymes such as MMPs and ADAMTSs. This evidence concerns the gene NFKB1 and intervertebral disk degenerative disorder.