The authors tested for an association between lumbar disc degeneration and DNA methylation variants at three CpG sites in the PARK2 promoter. A significant association between DNA methylation at CpG site cg15832436 and LDD (β = 8.74 × 10−4, SE = 2.49 × 10−4, p = 0.006) was observed. A positive trend was also observed for the other two loci, though without reaching significance. This evidence concerns the gene PRKN and lumbar disk degenerative disorder.