HMOX1 and fibrosis: In an irradiation-induced model of fibrosis, EGCG decreased a severity of lung histological changes, lowered levels of malonyldialdehyde (a marker of lipid peroxidation) in the lungs and serum levels of TGF-β1, IL-6, IL-10, and TNFα, activated Nrf2 and associated antioxidant enzymes HO-1 and NQO-1, enhanced activity of SOD, and lowered collagen deposition and (myo)fibroblast proliferation [44].