In the first approach, we tested the influence of 262 natural products (a subset of the German Center for Infection Research (DZIF) Natural Compound Library, containing 88 compounds derived from fungi and 174 natural products from bacteria and fungi from BioViotica Naturstoffe GmbH, Dransfeld, Germany) with high structural and functional diversity on the Agd3 enzymatic activity. Here, C12orf75 is linked to infection.