The importance of isolated subpial p-Tau astrocytes in the depths of sulci without any neurofibrillary tangles near perivascular areas in the underlying cortex is unknown, but subpial p-Tau astrocytes at the deep cortical sulci is not a phenomenon found in normal aging and has been found in the brains of individuals with a history of chronic repetitive brain trauma [2,11]. The gene discussed is MAPT; the disease is injury.