In addition, other important LACC1 pathogenic mutations have been associated with JIA, such as C284R (c.850T > C, p.Cys284Arg), which has been found in several consanguineous sJIA patients, and the frameshift p.Cys43Tyrfs*6 and p.T276fs*2 mutations, which have been confirmed respectively in severe oJIA and RF − pJIA patients [84,109]. The gene discussed is LACC1; the disease is juvenile idiopathic arthritis.