Many of these genes are widely expressed in haematopoietic tissues, including neutrophils and monocytes, and generally involved in T cell regulation and modulation, underlying once again the central role of both innate immune responses and adaptive immunity, through the modulation of many proinflammatory cytokines, including TNFα, highlighting interactions with each other in JIA pathophysiology [90]. Here, TNF is linked to juvenile idiopathic arthritis.