The intriguing results obtained by Zhang and co-authors showed that the alternative splicing of the LHFPL3-AS1 precursor in melanoma stem cells is mediated by the PTBP1 (Polypyrimidine Tract Binding Protein 1) which, by binding to a specific motif (UCUCU) in exon three of the LHFPL3-AS1 precursor, favours its inclusion in the mature transcript. This evidence concerns the gene PTBP1 and melanoma.