In melanoma, a recent paper unveiled a regulatory circuit centered on the lncRNA LHFPL3-AS1 (LHFPL3 Antisense RNA 1): by sequestering miR-181a-5p, it positively affects the expression of BCL2 (B-cell lymphoma 2), thus inhibiting the apoptosis of melanoma cells, and in particular melanoma stem cells [60]. The gene discussed is LHFPL3; the disease is melanoma.