This is the case of Ji J. and collaborators’ work [41], where the lncRNA SChLAP1 (Second Chromosome Locus Associated with Prostate-1) is shown to bind to HNRNPL (Heterogeneous Nuclear Ribonucleoprotein L) in glioblastoma cells, both stem, and non-stem; the formation of the protein–RNA complex stabilizes SChLAP1 and promotes the interaction between HNRNPL and ACTN4 (Actinin Alpha 4), in turn increasing the stability of the ACTN4 protein by inhibiting its ubiquitination and proteasomal degradation. The gene discussed is ACTN4; the disease is glioblastoma.