CXCL8 and Hyperglycemia: In contrast, in another study dapa-, empa-, and canagliflozin did not prevent an increase in the mRNA expression of IL-6, IL-8, and IL-1β (induced by LPS in monocytes or by hyperglycemia in endothelial cells), suggesting that these drugs do not have intrinsic anti-inflammatory properties in these situations [47].