INS and type 1 diabetes mellitus: The use of human insulin in the treatment of patients with T1DM gradually declined (SC: 71.4 to 37.5%, p < 0.001; TC: 68.9 to 19.5%, p < 0.001), while the use of insulin analogues remarkably increased over the same period (SC: 23.7 to 69.6%, p < 0.001; TC: 17.6 to 77.4%, p < 0.001).