The risk of transmission of newly reported HIV infections infected of the subtype CRF01_AE in this area is higher than that of newly reported HIV infections of the subtype CRF07_BC, while the CD4(+) T-cell recovery of newly reported HIV infections of the subtype CRF01_AE is worse than that of subtype CRF07_BC infections. The gene discussed is CD4; the disease is HIV infectious disease.