In summary, like SAT, GD may also present both after infection with SARS-CoV-2 and vaccine against SARS-CoV-2, suggesting that protein S has the potential to induce or unmask autoimmunity in genetically predisposed individuals, although it is still unclear if its onset may also depend on the bystander effect of adjuvants [126]. The gene discussed is PROS1; the disease is Autoimmunity.