In particular, eight cases were diagnosed with GD, the most frequent cause of hyperthyroidism in iodine-sufficient areas and especially in middle-aged women, characterized by low TSH and raised serum concentrations of thyroid hormones, presence of TSH receptor antibodies and thyroid stimulating immunoglobulins, and hypoechoic pattern and increased vascularity at ultrasound [12,95]. This evidence concerns the gene TG and hyperthyroidism.