IL6 and COVID-19: Notably, the hyperinflammatory status associated with COVID-19 seems to be primarily mediated by T helper (Th) 1-type cytokines as well as IL-6, and a prevalent Th1 immune response (not related to the hyperthyroidism per se, but to the autoimmune process) has also been reported in the immune-pathogenesis of GD [97,101].