Similarly, during the last two years, the notable research results cited frequently related to lipid accumulation, delineate lncRNA kcnq1ot1, promote lipid accumulation and accelerate atherosclerosis by functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis [18], and the demethylation of mRNA regulated by FTO can induce lipid accumulation in hepatocytes [19], etc. The above results illustrate that “metabolic reprogramming” and “lipid accumulation” may be major parts that are influenced by epigenetics in lipid metabolism. Here, HDAC3 is linked to atherosclerosis.